Targeting MYCN in Molecularly Defined Malignant Brain Tumors.
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ABSTRACT:
SUBMITTER: Borgenvik A
PROVIDER: S-EPMC7877538 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Targeting MYCN in Molecularly Defined Malignant Brain Tumors.
Borgenvik Anna A Čančer Matko M Hutter Sonja S Swartling Fredrik J FJ
Frontiers in oncology 20210128
Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is frequently found in malignant brain tumors highlighting their important roles as oncogenes. Brain tumors in children are the most lethal of all pediatric malignancies and the most common malignant primary adult brain tumor, glioblastoma, is still practically incurable. MYCN is one of three MYC family members and is crucial for normal brain development. It is associated with poor prognosis in many malignant pediat ...[more]
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