Assessment of dynamic cardiac repolarization and contractility in patients with hypertrophic cardiomyopathy.

ABSTRACT:

Aims

Arrhythmia mechanisms in hypertrophic cardiomyopathy remain uncertain. Preclinical models suggest hypertrophic cardiomyopathy-linked mutations perturb sarcomere length-dependent activation, alter cardiac repolarization in rate-dependent fashion and potentiate triggered electrical activity. This study was designed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy.

Methods

All participants had a cardiac implantable device capable of atrial pacing. Cases had clinical diagnosis of hypertrophic cardiomyopathy, controls were age-matched. Continuous electrocardiogram and blood pressure were recorded during and immediately after 30 second pacing trains delivered at increasing rates.

Results

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SUBMITTER: Radbill AE 

PROVIDER: S-EPMC7877626 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature