Context-aware dimensionality reduction deconvolutes gut microbial community dynamics.
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ABSTRACT:
SUBMITTER: Martino C
PROVIDER: S-EPMC7878194 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Context-aware dimensionality reduction deconvolutes gut microbial community dynamics.
Martino Cameron C Shenhav Liat L Marotz Clarisse A CA Armstrong George G McDonald Daniel D Vázquez-Baeza Yoshiki Y Morton James T JT Jiang Lingjing L Dominguez-Bello Maria Gloria MG Swafford Austin D AD Halperin Eran E Knight Rob R
Nature biotechnology 20200831 2
The translational power of human microbiome studies is limited by high interindividual variation. We describe a dimensionality reduction tool, compositional tensor factorization (CTF), that incorporates information from the same host across multiple samples to reveal patterns driving differences in microbial composition across phenotypes. CTF identifies robust patterns in sparse compositional datasets, allowing for the detection of microbial changes associated with specific phenotypes that are r ...[more]
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