Ontology highlight
ABSTRACT:
SUBMITTER: Hartmann FJ
PROVIDER: S-EPMC7878201 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Hartmann Felix J FJ Mrdjen Dunja D McCaffrey Erin E Glass David R DR Greenwald Noah F NF Bharadwaj Anusha A Khair Zumana Z Verberk Sanne G S SGS Baranski Alex A Baskar Reema R Graf William W Van Valen David D Van den Bossche Jan J Angelo Michael M Bendall Sean C SC
Nature biotechnology 20200831 2
Cellular metabolism regulates immune cell activation, differentiation and effector functions, but current metabolic approaches lack single-cell resolution and simultaneous characterization of cellular phenotype. In this study, we developed an approach to characterize the metabolic regulome of single cells together with their phenotypic identity. The method, termed single-cell metabolic regulome profiling (scMEP), quantifies proteins that regulate metabolic pathway activity using high-dimensional ...[more]