CRIg⁺ Macrophages Prevent Gut Microbial DNA-Containing Extracellular Vesicle-Induced Tissue Inflammation and Insulin Resistance.

ABSTRACT:

Background & aims

Liver CRIg⁺ (complement receptor of the immunoglobulin superfamily) macrophages play a critical role in filtering bacteria and their products from circulation. Translocation of microbiota-derived products from an impaired gut barrier contributes to the development of obesity-associated tissue inflammation and insulin resistance. However, the critical role of CRIg⁺ macrophages in clearing microbiota-derived products from the bloodstream in the context of obesity is largely unknown.

Methods

We performed studies with CRIg^-/-, C3^-/-, cGAS^-/-, and their wild-type littermate mice. The CRIg⁺ macrophage population and bacterial DNA abundance were examined in both mouse and human liver by either flow

SUBMITTER: Luo Z 

PROVIDER: S-EPMC7878308 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature