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Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy.


ABSTRACT: The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0-1, II: 2-4, and III: 5-7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer with increasing O-grades, and the renal survival rate by the Kaplan-Meier method was 94.1%, 86.9%, and 74.1% for O-grades I, II, and III, respectively. The hazard ratios (HRs) for O-grades II and III with reference to O-grade I were 2.8 (95% confidence interval [CI] 1.3-6.0) and 6.3 (95% CI 2.7-14.5), respectively. In the multivariate analysis, mean arterial pressure and eGFR, proteinuria at the time of biopsy, treatment of corticosteroids/immunosuppressors, and O-grade (HR 1.63; 95% CI 1.11-2.38) were the independent factors predicting renal prognosis. Among the nine groups classified using the O-grade and Japanese clinical-grade, the renal prognosis had an HR of 15.2 (95% CI 3.5-67) in the severest group. The O-grade classified by the total score of the Oxford classification was associated with renal prognosis.

SUBMITTER: Miyabe Y 

PROVIDER: S-EPMC7878747 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Grading system utilising the total score of Oxford classification for predicting renal prognosis in IgA nephropathy.

Miyabe Yoei Y   Karasawa Kazunori K   Akiyama Kenichi K   Ogura Shota S   Takabe Tomo T   Sugiura Naoko N   Seki Momoko M   Iwabuchi Yuko Y   Hanafusa Norio N   Uchida Keiko K   Nitta Kosaku K   Moriyama Takahito T  

Scientific reports 20210211 1


The Oxford classification of IgA nephropathy (IgAN) can evaluate each MEST-C score individually. We analysed a new grading system that utilised the total MEST-C score in predicting renal prognosis. Altogether, 871 IgAN patients were classified into three groups using the new Oxford classification system (O-grade) that utilised the total MEST-C score (O-grade I: 0-1, II: 2-4, and III: 5-7 points), and the 10-year renal prognosis was analysed. The clinical findings became significantly severer wit  ...[more]

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