Dataset Information

Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.

ABSTRACT:

Objectives

To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population.

Design

Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.

Setting

Multicentric study conducted in Australia and the United States.

Participants

A total of 19,110 older adults (mean age = 75?years [standard deviation = ±4.5]).

Measurements

Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders.

Results

Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07-1.32), diabetes (OR = 1.22; 95% CI = 1.05-1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28-1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03-1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27-1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10-1.42), history of cancer (OR = 1.19; 95% CI = 1.05-1.34), Parkinson's disease (OR = 2.56; 95% CI = 1.83-3.56), polypharmacy (OR = 1.60; 95% CI = 1.44-1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12-1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P >?.05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13-1.22).

Conclusion

Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals. J Am Geriatr Soc 68:1834-1841, 2020.

SUBMITTER: Agustini B

PROVIDER: S-EPMC7879564 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.

Agustini Bruno B Lotfaliany Mojtaba M Woods Robyn L RL McNeil John J JJ Nelson Mark R MR Shah Raj C RC Murray Anne M AM Ernst Michael E ME Reid Christopher M CM Tonkin Andrew A Lockery Jessica E JE Williams Lana J LJ Berk Michael M Mohebbi Mohammadreza M

Journal of the American Geriatrics Society 20200513 8

<h4>Objectives</h4>To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population.<h4>Design</h4>Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.<h4>Setting</h4>Multicentric study conducted in Australia and the United States.<h4>Participants</h4>A total of 19,110 older adults (mean age = 75 years [standard deviation = ±4.5]).<h4>Measurements</h4>Depressive symp ...[more]

PMID: 32402115

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Dataset Information

Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.

Objectives

Design

Setting

Participants

Measurements

Results

Conclusion

Publications

Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults.

Similar Datasets

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