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Serum response factor, a novel early diagnostic biomarker of acute kidney injury.
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ABSTRACT: Objective
Studies have shown that serum response factor (SRF) is increased in chronic kidney injury, such as diabetic nephropathy, hyperuricemic nephropathy and renal cell carcinoma. The objective is to explore the early diagnostic value of SRF in acute kidney injury (AKI).Methods
AKI-related microarray data were analyzed, and the expression and location of SRF were investigated in the early phase of AKI.Results
Bioinformatics results demonstrated that SRF was dramatically elevated 2-4 h after ischemia/reperfusion (I/R) in mouse renal tissue. In I/R rats, SRF was mostly expressed and located in renal tubular epithelial cells (TECs). SRF started to increase at 1 h, peaked at 3-9 h and started to decrease at 12 h after I/R. The areas under the ROC curve of renal SRF mRNA, renal SRF protein, urinary SRF, serum SRF and serum creatinine (Scr) were 87.9%, 83.0%, 81.3%, 78.8%, 68.8%, respectively.Conclusion
SRF is remarkably upregulated in early (before 24 h) AKI and can replace Scr as a potential new early diagnostic biomarker of AKI.
SUBMITTER: Zhao L
PROVIDER: S-EPMC7880358 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Serum response factor, a novel early diagnostic biomarker of acute kidney injury.
Aging 20210105 2
<h4>Objective</h4>Studies have shown that serum response factor (SRF) is increased in chronic kidney injury, such as diabetic nephropathy, hyperuricemic nephropathy and renal cell carcinoma. The objective is to explore the early diagnostic value of SRF in acute kidney injury (AKI).<h4>Methods</h4>AKI-related microarray data were analyzed, and the expression and location of SRF were investigated in the early phase of AKI.<h4>Results</h4>Bioinformatics results demonstrated that SRF was dramaticall ...[more]
