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Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

ABSTRACT: Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used Drosophila to search for genes functionally related to the NG2 homologue kon-tiki (kon), and identified Islet Antigen-2 (Ia-2), required in neurons for insulin secretion. Both loss and over-expression of ia-2 induced neural stem cell gene expression, injury increased ia-2 expression and induced ectopic neural stem cells. Using genetic analysis and lineage tracing, we demonstrate that Ia-2 and Kon regulate Drosophila insulin-like peptide 6 (Dilp-6) to induce glial proliferation and neural stem cells from glia. Ectopic neural stem cells can divide, and limited de novo neurogenesis could be traced back to glial cells. Altogether, Ia-2 and Dilp-6 drive a neuron-glia relay that restores glia and reprogrammes glia into neural stem cells for regeneration.

SUBMITTER: Harrison NJ

PROVIDER: S-EPMC7880684 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

Harrison Neale J NJ Connolly Elizabeth E Gascón Gubieda Alicia A Yang Zidan Z Altenhein Benjamin B Losada Perez Maria M Moreira Marta M Sun Jun J Hidalgo Alicia A

eLife 20210202

Understanding how injury to the central nervous system induces de novo neurogenesis in animals would help promote regeneration in humans. Regenerative neurogenesis could originate from glia and glial neuron-glia antigen-2 (NG2) may sense injury-induced neuronal signals, but these are unknown. Here, we used Drosophila to search for genes functionally related to the NG2 homologue kon-tiki (kon), and identified Islet Antigen-2 (Ia-2), required in neurons for insulin secr ...[more]

PMID: 33527895

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Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

Publications

Regenerative neurogenic response from glia requires insulin-driven neuron-glia communication.

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