Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation.
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ABSTRACT:
SUBMITTER: Kinsler G
PROVIDER: S-EPMC7880691 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation.
Kinsler Grant G Geiler-Samerotte Kerry K Petrov Dmitri A DA
eLife 20201202
Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive yeast mutants responds to subtle environmental shifts. We then model the number of phenotypes these mutations collectively influence by decomposing these patterns of fitness variati ...[more]
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