ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer.
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ABSTRACT: Background/aim
Adjuvant chemotherapy for high-risk Stage II colorectal cancer (CRC) is weakly recommended; however, no consensus exists on "high-risk" definition. Prognostic biomarker identification is important for selecting patients with poor prognosis who may benefit from adjuvant chemotherapy.Materials and methods
Using Microarray data analyses, ELF3 was identified as a candidate gene highly expressed in Stage II CRC with distant recurrences. ELF3 mRNA expression in 168 Stage II CRC patients was subjected to quantitative RT-PCR analysis and ELF3 protein expression in 185 patients was quantified by immunohistochemical analysis. The relationship between mRNA and protein expression levels and patient characteristics were also investigated.Results
The overall recurrence rate and relapse-free survival were significantly poorer in the ELF3 high-expression than the low-expression group at the mRNA and protein levels. High ELF3 mRNA and protein expression levels were independent poor prognostic factors.Conclusion
High ELF3 expression was associated with recurrence of Stage II.
SUBMITTER: Takaoka A
PROVIDER: S-EPMC7880722 | biostudies-literature | 2021 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
ELF3 Overexpression as Prognostic Biomarker for Recurrence of Stage II Colorectal Cancer.
Takaoka Ayumi A Ishikawa Toshiaki T Okazaki Satoshi S Watanabe Shuichi S Miya Fuyuki F Tsunoda Tatsuhiko T Kikuchi Akifumi A Yamauchi Shinichi S Matsuyama Takatoshi T Tokunaga Masanori M Uetake Hiroyuki H Kinugasa Yusuke Y
In vivo (Athens, Greece) 20210101 1
<h4>Background/aim</h4>Adjuvant chemotherapy for high-risk Stage II colorectal cancer (CRC) is weakly recommended; however, no consensus exists on "high-risk" definition. Prognostic biomarker identification is important for selecting patients with poor prognosis who may benefit from adjuvant chemotherapy.<h4>Materials and methods</h4>Using Microarray data analyses, ELF3 was identified as a candidate gene highly expressed in Stage II CRC with distant recurrences. ELF3 mRNA expression in 168 Stage ...[more]
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