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ABSTRACT: Objectives
To assess the combined role of tumor vascularity, estimated from perfusion MRI, and MGMT methylation status on overall survival (OS) in patients with glioblastoma.Methods
A multicentric international dataset including 96 patients from NCT03439332 clinical study were used to study the prognostic relationships between MGMT and perfusion markers. Relative cerebral blood volume (rCBV) in the most vascularized tumor regions was automatically obtained from preoperative MRIs using ONCOhabitats online analysis service. Cox survival regression models and stratification strategies were conducted to define a subpopulation that is particularly favored by MGMT methylation in terms of OS.Results
rCBV distributions did not differ significantly (p?>?0.05) in the methylated and the non-methylated subpopulations. In patients with moderately vascularized tumors (rCBV ?10.73), however, there was no significant effect of MGMT methylation (HR?=?1.72, p?=?0.10, AUC?=?0.56).Conclusions
Our results indicate the existence of complementary prognostic information provided by MGMT methylation and rCBV. Perfusion markers could identify a subpopulation of patients who will benefit the most from MGMT methylation. Not considering this information may lead to bias in the interpretation of clinical studies.Key points
• MRI perfusion provides complementary prognostic information to MGMT methylation. • MGMT methylation improves prognosis in glioblastoma patients with moderate vascular profile. • Failure to consider these relations may lead to bias in the interpretation of clinical studies.
SUBMITTER: Fuster-Garcia E
PROVIDER: S-EPMC7880975 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Fuster-Garcia Elies E Lorente Estellés David D Álvarez-Torres María Del Mar MDM Juan-Albarracín Javier J Chelebian Eduard E Rovira Alex A Acosta Cristina Auger CA Pineda Jose J Oleaga Laura L Mollá-Olmos Enrique E Filice Silvano S Due-Tønnessen Paulina P Meling Torstein R TR Emblem Kyrre E KE García-Gómez Juan M JM
European radiology 20201001 3
<h4>Objectives</h4>To assess the combined role of tumor vascularity, estimated from perfusion MRI, and MGMT methylation status on overall survival (OS) in patients with glioblastoma.<h4>Methods</h4>A multicentric international dataset including 96 patients from NCT03439332 clinical study were used to study the prognostic relationships between MGMT and perfusion markers. Relative cerebral blood volume (rCBV) in the most vascularized tumor regions was automatically obtained from preoperative MRIs ...[more]