Ontology highlight
ABSTRACT:
SUBMITTER: Khan A
PROVIDER: S-EPMC7881014 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Khan Aaminah A Gamble Laura D LD Upton Dannielle H DH Ung Caitlin C Yu Denise M T DMT Ehteda Anahid A Pandher Ruby R Mayoh Chelsea C Hébert Steven S Jabado Nada N Kleinman Claudia L CL Burns Mark R MR Norris Murray D MD Haber Michelle M Tsoli Maria M Ziegler David S DS
Nature communications 20210212 1
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small organic polycations that are essential for DNA replication, translation and cell proliferation. Ornithine decarboxylase 1 (ODC1), the rate-limiting enzyme in polyamine synthesis, is irreversibly inhibited by difluoromethylornithine (DFMO). Herein we show that polyamine synthesis is upregulated in DIPG, leading to se ...[more]