Delivery-based criteria for empiric antibiotic administration among preterm infants.
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ABSTRACT: Objective
Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. STUDY DESIGN: Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-series analyses.Results
After 04/2017, antibiotic initiation ?3 days decreased among low-risk VLBW (62% vs. 13%, p?ConclusionDelivery criteria may be used to optimize early antibiotic initiation among preterm infants without short-term increase in adverse outcomes.
SUBMITTER: Garber SJ
PROVIDER: S-EPMC7881045 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Delivery-based criteria for empiric antibiotic administration among preterm infants.
Garber Samuel J SJ Dhudasia Miren B MB Flannery Dustin D DD Passarella Molly R MR Puopolo Karen M KM Mukhopadhyay Sagori S
Journal of perinatology : official journal of the California Perinatal Association 20200813 2
<h4>Objective</h4>Determine impact of using delivery criteria to initiate antibiotics among very low birth weight (VLBW) and extremely low birth weight (ELBW) infants. STUDY DESIGN: Single site cohort study from 01/01/2009 to 01/31/2020. After 04/2017, infants delivered by Cesarean section, without labor or membrane rupture were categorized as low-risk for early-onset infection and managed without empiric antibiotics. We determined effect of this guideline by pre-post, and interrupted time-serie ...[more]
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