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The IL-27 receptor regulates TIGIT on memory CD4⁺ T cells during sepsis.

ABSTRACT: Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD-1, we assessed whether IL-27 impacts these co-inhibitory molecules in sepsis. Based on these data, we hypothesized that IL-27 was responsible for T cell dysfunction during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we found that IL-27R? was associated with the upregulation of TIGIT on memory CD4⁺ T cells following CLP. However, IL-27 was not associated with sepsis mortality.

SUBMITTER: Morrow KN

PROVIDER: S-EPMC7881227 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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The IL-27 receptor regulates TIGIT on memory CD4+ T cells during sepsis.

Morrow Kristen N KN Liang Zhe Z Xue Ming M Chihade Deena B DB Sun Yini Y Chen Ching-Wen CW Coopersmith Craig M CM Ford Mandy L ML

iScience 20210127 2

Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to recent studies describing IL-27 regulation of TIGIT and PD-1, we assessed whether IL-27 impacts these co-inhibitory molecules in sepsis. Based on these data, we hypothesized that IL-27 was responsible for T cell dysfunction during sepsis. Using the cecal lig ...[more]

PMID: 33615199

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