Ontology highlight
ABSTRACT:
SUBMITTER: Ziaunys M
PROVIDER: S-EPMC7881721 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Ziaunys Mantas M Sakalauskas Andrius A Mikalauskaite Kamile K Smirnovas Vytautas V
PeerJ 20210210
The aggregation of proteins is considered to be the main cause of several neurodegenerative diseases. Despite much progress in amyloid research, the process of fibrillization is still not fully understood, which is one of the main reasons why there are still very few effective treatments available. When the aggregation of insulin, a model amyloidogenic protein, is tracked using thioflavin-T (ThT), an amyloid specific dye, there is an anomalous occurrence of double-sigmoidal aggregation kinetics. ...[more]