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Healthcare resource utilization and associated cost of patients with bone metastases from solid tumors who are naive to bone-targeting agents: a comparative analysis of patients with and without skeletal-related events.


ABSTRACT:

Background

This study analyzes the impact of skeletal-related events (SRE) on healthcare resource utilization (HCRU) and costs incurred by patients with bone metastases (BM) from solid tumors (ST), who are therapy-naïve to bone targeting agents (BTAs).

Methods

German claims data from 01/01/2010 to 30/06/2018 were used to conduct a retrospective comparative cohort analysis of BTA-naive patients with a BM diagnosis and preceding ST diagnosis. HCRU and treatment-related costs were compared in two matched cohorts of patients with and without a history of SREs, defined as pathological fracture, spinal cord compression, surgery to bone and radiation to bone. The first SRE was defined as the patient-individual index date. Conversely, for the non-SRE patients, index dates were assigned randomly.

Results

In total, 45.20% of 9,832 patients reported experiencing at least one SRE (n?=?4444) while 54.80% experienced none (n?=?5388); 2,434 pairs of SRE and non-SRE patients were finally matched (mean age: 70.87/71.07 years; females: 39.07%/38.58%). Between SRE and non-SRE cohorts, significant differences in the average number of hospitalization days per patient-year (35.80/30.80) and associated inpatient-care costs (14,199.27€/10,787.31€) were observed. The total cost ratio was 1.16 (p?ConclusionThe underutilization of BTAs within a clinical setting poses an ongoing challenge in the real-world treatment of BM patients throughout Germany. Ultimately, the economic burden of treating SREs in patients with BM from ST was found to be considerable, resulting in higher direct healthcare costs and increased utilization of inpatient care facilities.

SUBMITTER: Hardtstock F 

PROVIDER: S-EPMC7881971 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Healthcare resource utilization and associated cost of patients with bone metastases from solid tumors who are naïve to bone-targeting agents: a comparative analysis of patients with and without skeletal-related events.

Hardtstock Fränce F   Kocaata Zeki Z   Wilke Thomas T   Dittmar Axel A   Ghiani Marco M   Belozeroff Vasily V   Harrison David J DJ   Maywald Ulf U   Tesch Hans H  

The European journal of health economics : HEPAC : health economics in prevention and care 20210118 2


<h4>Background</h4>This study analyzes the impact of skeletal-related events (SRE) on healthcare resource utilization (HCRU) and costs incurred by patients with bone metastases (BM) from solid tumors (ST), who are therapy-naïve to bone targeting agents (BTAs).<h4>Methods</h4>German claims data from 01/01/2010 to 30/06/2018 were used to conduct a retrospective comparative cohort analysis of BTA-naive patients with a BM diagnosis and preceding ST diagnosis. HCRU and treatment-related costs were co  ...[more]

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