CAMP levels regulate macrophage alternative activation marker expression.
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ABSTRACT:
SUBMITTER: Polumuri S
PROVIDER: S-EPMC7882807 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
cAMP levels regulate macrophage alternative activation marker expression.
Polumuri Swamy S Perkins Darren J DJ Vogel Stefanie N SN
Innate immunity 20201126 2
The capacity for macrophages to polarize into distinct functional activation states (e.g., M1, M2) is critical to tune an inflammatory response to the relevant infection or injury. Alternative or M2 polarization of macrophages is most often achieved <i>in vitro</i> in response to IL-4/IL-13 and results in the transcriptional up-regulation of a constellation of characteristic M2 marker genes. <i>In vivo</i>, additional signals from the inflammatory milieu can further increase or decrease M2 marke ...[more]
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