Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma.
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ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC7882927 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma.
Guo Yimin Y Shi Jianting J Wang Qiujie Q Hong Luna L Chen Ming M Liu Shanying S Yuan Xiaoqing X Jiang Shanping S
Journal of cellular and molecular medicine 20210109 4
Obesity increases the morbidity and severity of asthma, with poor sensitivity to corticosteroid treatment. Metformin has potential effects on improving asthma airway inflammation. Regulatory T cells (Tregs) play a key role in suppressing the immunoreaction to allergens. We built an obese asthmatic mouse model by administering a high-fat diet (HFD) and ovalbumin (OVA) sensitization, with daily metformin treatment. We measured the body weight and airway inflammatory status by histological analysis ...[more]
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