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ABSTRACT: Background
Carotid stenosis is a known risk factor for ischemic stroke, and carotid artery stenting is an effective preventive procedure. However, the stroke risk reduction for asymptomatic patients is small. Therefore, it is important to reduce the risk of complications, particularly in asymptomatic carotid stenosis. Statins are known to reduce the overall risk of periprocedural complications, although there is a lack of data focusing on asymptomatic patients. We aimed to investigate whether different doses of statin pretreatment can reduce periprocedural complications of carotid artery stenting (CAS) in patients with asymptomatic carotid artery stenosis.Methods
Between July 2003 and June 2013, 276 consecutive patients received CAS for asymptomatic carotid stenosis. Periprocedural complications included the outcome of stroke, myocardial infarction, or death within 30?days of CAS. Statin pretreatment was categorized as no-statin (n?=?87, 31.5%), standard-dose (ResultsThe overall periprocedural complication rate was 3.3%. There was no significant difference in the risk of periprocedural complications between the three groups (no statin: n?=?3 [3.4%]; standard-dose: n?=?4 [2.9%]; high-dose n?=?2 [4.0%] p?=?0.923). The CA trend test did not demonstrate a trend in the proportion of periprocedural complications across increasing statin equivalent doses (p?=?0.919).Conclusions
Statin pretreatment before CAS showed neither absolute nor dose-dependent effects against periprocedural complications in asymptomatic patients undergoing CAS.
SUBMITTER: Jang SH
PROVIDER: S-EPMC7883458 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Jang Seong Hwa SH Kwon Doo Hyuk DH Han Moon-Ku MK Park Hyungjong H Sohn Sung-Il SI Choi Huimahn H Hong Jeong-Ho JH
BMC neurology 20210215 1
<h4>Background</h4>Carotid stenosis is a known risk factor for ischemic stroke, and carotid artery stenting is an effective preventive procedure. However, the stroke risk reduction for asymptomatic patients is small. Therefore, it is important to reduce the risk of complications, particularly in asymptomatic carotid stenosis. Statins are known to reduce the overall risk of periprocedural complications, although there is a lack of data focusing on asymptomatic patients. We aimed to investigate wh ...[more]