Ontology highlight
ABSTRACT: Objective
We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers.Design
Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires.Settings
A multisite healthcare delivery system located in Los Angeles County.Participants
A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions.Main outcomes
Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection.Results
We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors.Conclusion and relevance
The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.
SUBMITTER: Ebinger JE
PROVIDER: S-EPMC7883610 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ebinger Joseph E JE Botwin Gregory J GJ Albert Christine M CM Alotaibi Mona M Arditi Moshe M Berg Anders H AH Binek Aleksandra A Botting Patrick P Fert-Bober Justyna J Figueiredo Jane C JC Grein Jonathan D JD Hasan Wohaib W Henglin Mir M Hussain Shehnaz K SK Jain Mohit M Joung Sandy S Karin Michael M Kim Elizabeth H EH Li Dalin D Liu Yunxian Y Luong Eric E McGovern Dermot P B DPB Merchant Akil A Merin Noah N Miles Peggy B PB Minissian Margo M Nguyen Trevor Trung TT Raedschelders Koen K Rashid Mohamad A MA Riera Celine E CE Riggs Richard V RV Sharma Sonia S Sternbach Sarah S Sun Nancy N Tourtellotte Warren G WG Van Eyk Jennifer E JE Sobhani Kimia K Braun Jonathan G JG Cheng Susan S
BMJ open 20210212 2
<h4>Objective</h4>We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers.<h4>Design</h4>Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires.<h4>Settings</h4>A multisite healthcare delivery system located in Los Angeles County.<h4>Participants</h4>A diverse and unselected population of adults (n=6062) employed in a multisite health ...[more]