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Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.


ABSTRACT:

Objective

We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers.

Design

Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires.

Settings

A multisite healthcare delivery system located in Los Angeles County.

Participants

A diverse and unselected population of adults (n=6062) employed in a multisite healthcare delivery system located in Los Angeles County, including individuals with direct patient contact and others with non-patient-oriented work functions.

Main outcomes

Using Bayesian and multivariate analyses, we estimated seroprevalence and factors associated with seropositivity and antibody levels, including pre-existing demographic and clinical characteristics; potential COVID-19 illness-related exposures; and symptoms consistent with COVID-19 infection.

Results

We observed a seroprevalence rate of 4.1%, with anosmia as the most prominently associated self-reported symptom (OR 11.04, p<0.001) in addition to fever (OR 2.02, p=0.002) and myalgias (OR 1.65, p=0.035). After adjusting for potential confounders, seroprevalence was also associated with Hispanic ethnicity (OR 1.98, p=0.001) and African-American race (OR 2.02, p=0.027) as well as contact with a COVID-19-diagnosed individual in the household (OR 5.73, p<0.001) or clinical work setting (OR 1.76, p=0.002). Importantly, African-American race and Hispanic ethnicity were associated with antibody positivity even after adjusting for personal COVID-19 diagnosis status, suggesting the contribution of unmeasured structural or societal factors.

Conclusion and relevance

The demographic factors associated with SARS-CoV-2 seroprevalence among our healthcare workers underscore the importance of exposure sources beyond the workplace. The size and diversity of our study population, combined with robust survey and modelling techniques, provide a vibrant picture of the demographic factors, exposures and symptoms that can identify individuals with susceptibility as well as potential to mount an immune response to COVID-19.

SUBMITTER: Ebinger JE 

PROVIDER: S-EPMC7883610 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Seroprevalence of antibodies to SARS-CoV-2 in healthcare workers: a cross-sectional study.

Ebinger Joseph E JE   Botwin Gregory J GJ   Albert Christine M CM   Alotaibi Mona M   Arditi Moshe M   Berg Anders H AH   Binek Aleksandra A   Botting Patrick P   Fert-Bober Justyna J   Figueiredo Jane C JC   Grein Jonathan D JD   Hasan Wohaib W   Henglin Mir M   Hussain Shehnaz K SK   Jain Mohit M   Joung Sandy S   Karin Michael M   Kim Elizabeth H EH   Li Dalin D   Liu Yunxian Y   Luong Eric E   McGovern Dermot P B DPB   Merchant Akil A   Merin Noah N   Miles Peggy B PB   Minissian Margo M   Nguyen Trevor Trung TT   Raedschelders Koen K   Rashid Mohamad A MA   Riera Celine E CE   Riggs Richard V RV   Sharma Sonia S   Sternbach Sarah S   Sun Nancy N   Tourtellotte Warren G WG   Van Eyk Jennifer E JE   Sobhani Kimia K   Braun Jonathan G JG   Cheng Susan S  

BMJ open 20210212 2


<h4>Objective</h4>We sought to determine the extent of SARS-CoV-2 seroprevalence and the factors associated with seroprevalence across a diverse cohort of healthcare workers.<h4>Design</h4>Observational cohort study of healthcare workers, including SARS-CoV-2 serology testing and participant questionnaires.<h4>Settings</h4>A multisite healthcare delivery system located in Los Angeles County.<h4>Participants</h4>A diverse and unselected population of adults (n=6062) employed in a multisite health  ...[more]

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