Ontology highlight
ABSTRACT:
SUBMITTER: Matias-Barrios VM
PROVIDER: S-EPMC7883873 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Matias-Barrios Victor M VM Radaeva Mariia M Song Yi Y Alperstein Zaccary Z Lee Ahn R AR Schmitt Veronika V Lee Joseph J Ban Fuqiang F Xie Ning N Qi Jianfei J Lallous Nada N Gleave Martin E ME Cherkasov Artem A Dong Xuesen X
Frontiers in oncology 20210201
Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In contrast, TOP2 catalytic inhibitors induce limited DNA damage, have low cytotoxicity, and are effective in suppressing cancer cell proliferation. They have been sought after to be prospective anticancer therapies. Herein the discovery of new TOP2 ca ...[more]