Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients.

ABSTRACT: The high infection rate and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) make it a world-wide pandemic. Individuals infected by the virus exhibited different degrees of symptoms, and most convalescent individuals have been shown to develop both cellular and humoral immune responses. However, virus-specific adaptive immune responses in severe patients during acute phase have not been thoroughly studied. Here, we found that in a group of COVID-19 patients with acute respiratory distress syndrome (ARDS) during hospitalization, most of them mounted SARS-CoV-2-specific antibody responses, including neutralizing antibodies. However, compared to healthy controls, the percentages and absolute numbers of both NK cells and CD8⁺ T cells were significantly re

SUBMITTER: Ni L 

PROVIDER: S-EPMC7884325 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature