Ontology highlight
ABSTRACT: Background
The impact of molecular aberrations on survival after resection of colorectal liver metastases (CLM) in patients with early-age-onset (EOCRC) versus late-age-onset colorectal cancer (LOCRC) is unknown.Methods
Patients who underwent liver resection for CLM with known RAS, BRAF and MSI status were retrospectively studied. The prognostic impact of RAS mutations by age was analysed with age as a categorical variable and a continuous variable.Results
The study included 573 patients, 192 with EOCRC and 381 with LOCRC. The younger the age of onset of CRC, the greater the negative impact on overall survival of RAS mutations in the LOCRC, EOCRC, and ?40 years (hazard ratio (HR), 1.64 (95% confidence interval (CI), 1.23-2.20), 2.03 (95% CI, 1.30-3.17), and 2.97 (95% CI, 1.44-6.14), respectively. Age-specific mortality risk and linear regression analysis also demonstrated that RAS mutations had a greater impact on survival in EOCRC than in LOCRC (slope: -4.07, 95% CI -8.10 to 0.04, P?=?0.047, R2?=?0.08).Conclusion
Among patients undergoing CLM resection, RAS mutations have a greater negative influence on survival in patients with EOCRC, more so in patients ?40 years, than in patients with LOCRC and should be considered as a prognostic factor in multidisciplinary treatment planning.
SUBMITTER: Jacome AA
PROVIDER: S-EPMC7884678 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Jácome Alexandre A AA Vreeland Timothy J TJ Johnson Benny B Kawaguchi Yoshikuni Y Wei Steven H SH Nancy You Y Y Vilar Eduardo E Vauthey Jean-Nicolas JN Eng Cathy C
British journal of cancer 20201119 4
<h4>Background</h4>The impact of molecular aberrations on survival after resection of colorectal liver metastases (CLM) in patients with early-age-onset (EOCRC) versus late-age-onset colorectal cancer (LOCRC) is unknown.<h4>Methods</h4>Patients who underwent liver resection for CLM with known RAS, BRAF and MSI status were retrospectively studied. The prognostic impact of RAS mutations by age was analysed with age as a categorical variable and a continuous variable.<h4>Results</h4>The study inclu ...[more]