Timing variability and midfrontal ~4 Hz rhythms correlate with cognition in Parkinson's disease.

ABSTRACT: Patients with Parkinson's disease (PD) can have significant cognitive dysfunction; however, the mechanisms for these cognitive symptoms are unknown. Here, we used scalp electroencephalography (EEG) to investigate the cortical basis for PD-related cognitive impairments during interval timing, which requires participants to estimate temporal intervals of several seconds. Time estimation is an ideal task demand for investigating cognition in PD because it is simple, requires medial frontal cortical areas, and recruits basic executive processes such as working memory and attention. However, interval timing has never been systematically studied in PD patients with cognitive impairments. We report three main findings. First, 71 PD patients had increased temporal variability compared to 37 demogr

SUBMITTER: Singh A 

PROVIDER: S-EPMC7884691 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature