Exploring the predictive value of lesion topology on motor function outcomes in a porcine ischemic stroke model.

ABSTRACT: Harnessing the maximum diagnostic potential of magnetic resonance imaging (MRI) by including stroke lesion location in relation to specific structures that are associated with particular functions will likely increase the potential to predict functional deficit type, severity, and recovery in stroke patients. This exploratory study aims to identify key structures lesioned by a middle cerebral artery occlusion (MCAO) that impact stroke recovery and to strengthen the predictive capacity of neuroimaging techniques that characterize stroke outcomes in a translational porcine model. Clinically relevant MRI measures showed significant lesion volumes, midline shifts, and decreased white matter integrity post-MCAO. Using a pig brain atlas, damaged brain structures included the insular cortex, soma

SUBMITTER: Scheulin KM 

PROVIDER: S-EPMC7884696 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature