HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome.
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ABSTRACT:
SUBMITTER: Golkaram M
PROVIDER: S-EPMC7884730 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome.
Golkaram Mahdi M Salmans Michael L ML Kaplan Shannon S Vijayaraghavan Raakhee R Martins Marta M Khan Nafeesa N Garbutt Cassandra C Wise Aaron A Yao Joyee J Casimiro Sandra S Abreu Catarina C Macedo Daniela D Costa Ana Lúcia AL Alvim Cecília C Mansinho André A Filipe Pedro P Marques da Costa Pedro P Fernandes Afonso A Borralho Paula P Ferreira Cristina C Aldeia Fernando F Malaquias João J Godsey Jim J So Alex A Pawlowski Traci T Costa Luis L Zhang Shile S Liu Li L
NPJ genomic medicine 20210215 1
Colorectal cancer (CRC) is one of the most lethal malignancies. The extreme heterogeneity in survival rate is driving the need for new prognostic biomarkers. Human endogenous retroviruses (hERVs) have been suggested to influence tumor progression, oncogenesis and elicit an immune response. We examined multiple next-generation sequencing (NGS)-derived biomarkers in 114 CRC patients with paired whole-exome and whole-transcriptome sequencing (WES and WTS, respectively). First, we demonstrate that t ...[more]
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