Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice.
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ABSTRACT:
SUBMITTER: Wen X
PROVIDER: S-EPMC7884811 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Qu-Zhuo-Tong-Bi Decoction Alleviates Gouty Arthritis by Regulating Butyrate-Producing Bacteria in Mice.
Wen Xianghui X Lou Yu Y Song Siyue S He Zhixing Z Chen Juan J Xie Zhijun Z Shi Xiaowei X Wen Chengping C Shao Tiejuan T
Frontiers in pharmacology 20210202
Qu-zhuo-tong-bi decoction (QZTBD) is a traditional Chinese medicine prescription used to treat hyperuricemia and gout with no obvious adverse effects. However, the mechanism by which QZTBD treats gout has not been fully explored. Here, we investigated the effects of QZTBD on gouty arthritis and its therapeutic mechanism from the perspective of the gut microbiome. Our results demonstrated that QZTBD was effective for reducing serum uric acid level and attenuating paw edema and mechanical allodyni ...[more]
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