Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease.

ABSTRACT:

Objective

To determine the associations between amyloid-PET, tau-PET, and atrophy with the behavioral/dysexecutive presentation of Alzheimer disease (AD), how these differ from amnestic AD, and how they correlate to clinical symptoms.

Methods

We assessed 15 patients with behavioral/dysexecutive AD recruited from a tertiary care memory clinic, all of whom had biologically defined AD. They were compared with 25 patients with disease severity- and age-matched amnestic AD and a group of 131 cognitively unimpaired (CU) elderly individuals. All participants were evaluated with amyloid-PET with [¹⁸F]AZD4694, tau-PET with [¹⁸F]MK6240, MRI, and neuropsychological testing.

Results

Voxelwise contrasts identified patterns of frontal cortical tau aggregation

SUBMITTER: Therriault J 

PROVIDER: S-EPMC7884976 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature