Dataset Information

Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea.

ABSTRACT:

Background

Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to increase with its greater use. This study aimed to investigate the clinical characteristics and risk factors of immediate HS to cefaclor over the most recent 5 years.

Methods

This retrospective study investigated 521 adverse drug reactions (ADRs) to cefaclor at pharmacovigilance centers at two tertiary hospitals from January 2014 to December 2018. In total, 459 patients with immediate HS to cefaclor were reviewed.

Results

A total of 459 cases of cefaclor immediate HS were included among 521 cefaclor ADRs, and anaphylaxis was recorded in 61.2%. Female sex (odds ratio 2.917, 95% confidence interval 2.397-3.550, P?ConclusionsCefaclor was found to elicit high proportions of immediate HS and anaphylaxis. Physicians ought to be cautious with prescribing cefaclor to females, individuals with hypertension, liver diseases, or asthma, and patients taking nonsteroidal anti-inflammatory drugs.

Trial registration

This study was retrospectively registered.

SUBMITTER: Rhyou HI

PROVIDER: S-EPMC7885353 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea.

Rhyou Hyo-In HI Doo Go-Eun GE Yoon Jiwon J Ha Chae-Yeon CY Nam Hee-Joo HJ Woo Sung-Dae SD Lee Youngsoo Y Nam Young-Hee YH Ye Young-Min YM

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20210215 1

<h4>Background</h4>Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to increase with its greater use. This study aimed to investigate the clinical characteristics and risk factors of immediate HS to cefaclor over the most recent 5 years.<h4>Methods</h4>This retrospective study investigated 521 adverse drug reactions (ADRs) to cefaclor at pharm ...[more]

PMID: 33588929

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Project description:ObjectivesThe indicator unexpectedly long length of stay (UL-LOS) is used to gain insight into quality and safety of care in hospitals. The calculation of UL-LOS takes patients' age, main diagnosis and main procedure into account. University hospitals have relatively more patients with a UL-LOS than other hospitals. Our main research question is whether the high number of patients with a UL-LOS in university hospitals is caused by differences in additional patient characteristics between university hospitals and other hospitals.DesignWe performed a cross-sectional study and used administrative data from 1 510 627 clinical admissions in 87 Dutch hospitals. Patients who died in hospital, stayed in hospital for 100 days or longer or whose country of residence was not the Netherlands were excluded from the UL-LOS indicator. We identified which patient groups were treated only in university hospitals or only in other hospitals and which were treated in both hospital types. For these last patient groups, we added supplementary patient characteristics to the current model to determine the effect on the UL-LOS model.ResultsPatient groups treated in both hospital types differed in terms of detailed primary diagnosis, socioeconomic status, source of admission, type of admission and amount of Charlson comorbidities. Nevertheless, when adding these characteristics to the current model, university hospitals still have a significantly higher mean UL-LOS score compared with other hospitals (p<0.001).ConclusionsThe difference in UL-LOS scores between both hospital types remains after adding patient characteristics in which both hospital types differ. We conclude that the high UL-LOS scores in university hospitals are not caused by the investigated additional patient characteristics that differ between university and other hospitals. Patients might stay relatively longer in university hospitals due to differences in work processes because of their education and research tasks or financing differences of both hospital types.

Dataset Information

Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea.

Background

Methods

Results

Trial registration

Publications

Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea.

Similar Datasets

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