Relationships between plasma levels and six proinflammatory interleukins and body composition using a new magnetic resonance imaging voxel-based technique.

ABSTRACT:

Background

Obesity has previously been linked to inflammation. Here we investigated how plasma levels of six interleukins were related to body fat distribution.

Methods

In 321 subjects, all aged 50 years, in the population-based POEM study (mean BMI 26-27 kg/m²), six interleukins were measured together with a DXA scan for determination of fat and lean mass. Also a whole-body magnetic resonance imaging (MRI) scan, in which fat content measurements were acquired in > 1 million voxels was performed. Interleukin levels were related to each of these voxels by the voxel-based technique "Imiomics" to create a 3D-view of how these measurements were related to size of each part of the body.

Results

Levels of IL-1RA and IL-6 were related to traditional DXA and MRI me

SUBMITTER: Strand R 

PROVIDER: S-EPMC7885882 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature