Ontology highlight
ABSTRACT:
SUBMITTER: Feldman J
PROVIDER: S-EPMC7885909 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Feldman Jared J Bals Julia J Altomare Clara G CG St Denis Kerri K Lam Evan C EC Hauser Blake M BM Ronsard Larance L Sangesland Maya M Moreno Thalia Bracamonte TB Okonkwo Vintus V Hartojo Nathania N Balazs Alejandro B AB Bajic Goran G Lingwood Daniel D Schmidt Aaron G AG
bioRxiv : the preprint server for biology 20210709
Exposure to a pathogen elicits an adaptive immune response aimed to control and eradicate. Interrogating the abundance and specificity of the naive B cell repertoire contributes to understanding how to potentially elicit protective responses. Here, we isolated naive B cells from 8 seronegative human donors targeting the SARS-CoV-2 receptor-binding domain (RBD). Single B cell analysis showed diverse gene usage with no restricted complementarity determining region lengths. We show that recombinant ...[more]