Ontology highlight
ABSTRACT:
SUBMITTER: Tarakad A
PROVIDER: S-EPMC7886054 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Faculty reviews 20201110
Though primarily a sporadic condition, Parkinson's disease is increasingly recognized to be a multifactorial disease with a strong genetic component. At a cellular level, disruptions of protein trafficking and recycling, particularly by misfolding, accumulation, and aggregation of α-synuclein, mitochondrial dysfunction, oxidative stress, and other etiopathogenic mechanisms, have been found to result in the death of vulnerable neuronal populations and appear to drive the neurodegeneration underly ...[more]