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ABSTRACT: Background
Technique failure in peritoneal dialysis (PD) can be due to patient- and procedure-related factors. With this analysis, we investigated the association of volume overload at the start and during the early phase of PD and technique failure.Methods
In this observational, international cohort study with longitudinal follow-up of incident PD patients, technique failure was defined as either transfer to haemodialysis or death, and transplantation was considered as a competing risk. We explored parameters at baseline or within the first 6?months and the association with technique failure between 6 and 18?months, using a competing risk model.Results
Out of 1092 patients of the complete cohort, 719 met specific inclusion and exclusion criteria for this analysis. Being volume overloaded, either at baseline or Month 6, or at both time points, was associated with an increased risk of technique failure compared with the patient group that was euvolaemic at both time points. Undergoing treatment at a centre with a high proportion of PD patients was associated with a lower risk of technique failure.Conclusions
Volume overload at start of PD and/or at 6?months was associated with a higher risk of technique failure in the subsequent year. The risk was modified by centre characteristics, which varied among regions.
SUBMITTER: Vrtovsnik F
PROVIDER: S-EPMC7886558 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Vrtovsnik François F Verger Christian C Van Biesen Wim W Fan Stanley S Shin Sug-Kyun SK Rodríguez Carmen C Garcia Méndez Isabel I van der Sande Frank M FM De Los Ríos Tatiana T Ihle Katharina K Gauly Adelheid A Ronco Claudio C Heaf James J
Clinical kidney journal 20191222 2
<h4>Background</h4>Technique failure in peritoneal dialysis (PD) can be due to patient- and procedure-related factors. With this analysis, we investigated the association of volume overload at the start and during the early phase of PD and technique failure.<h4>Methods</h4>In this observational, international cohort study with longitudinal follow-up of incident PD patients, technique failure was defined as either transfer to haemodialysis or death, and transplantation was considered as a competi ...[more]