TGF-? Signaling Promotes Glioma Progression Through Stabilizing Sox9.
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ABSTRACT:
SUBMITTER: Chao M
PROVIDER: S-EPMC7886799 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9.
Chao Min M Liu Nan N Sun Zhichuan Z Jiang Yongli Y Jiang Tongtong T Xv Meng M Jia Lintao L Tu Yanyang Y Wang Liang L
Frontiers in immunology 20210203
Gliomas are brain and spinal cord malignancies characterized by high malignancy, high recurrence and poor prognosis, the underlying mechanisms of which remain largely elusive. Here, we found that the Sry-related high mobility group box (Sox) family transcription factor, Sox9, was upregulated and correlated with poor prognosis of clinical gliomas. Sox9 promotes migration and invasion of glioma cells and <i>in vivo</i> development of xenograft tumors from inoculated glioma cells. Sox9 functions do ...[more]
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