Ontology highlight
ABSTRACT:
SUBMITTER: Li APY
PROVIDER: S-EPMC7886864 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Li Athena P Y APY Cohen Carolyn A CA Leung Nancy H L NHL Fang Vicky J VJ Gangappa Shivaprakash S Sambhara Suryaprakash S Levine Min Z MZ Iuliano A Danielle AD Perera Ranawaka A P M RAPM Ip Dennis K M DKM Peiris J S Malik JSM Thompson Mark G MG Cowling Benjamin J BJ Valkenburg Sophie A SA
NPJ vaccines 20210216 1
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and antibody responses of S-IIV versus enhanced vaccines (eIIV): MF59-adjuvanted (A-eIIV), high-dose (H-eIIV), and recombinant-hemagglutinin (HA) (R-eIIV). All vaccines induced comparable H3-HA-specific IgG and elevated antibody-dependent cellular cytoto ...[more]