Ontology highlight
ABSTRACT:
SUBMITTER: Ning Z
PROVIDER: S-EPMC7886991 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Frontiers in genetics 20210203
The ever-growing genome-wide association studies (GWAS) have revealed widespread pleiotropy. To exploit this, various methods that jointly consider associations of a genetic variant with multiple traits have been developed. Most efforts have been made concerning improving GWAS discovery power. However, how to replicate these discovered pleiotropic loci has yet to be discussed thoroughly. Unlike a single-trait scenario, multi-trait replication is not trivial considering the underlying genotype-mu ...[more]