Sexual Differences in Genetic Predisposition of Coronary Artery Disease.

ABSTRACT:

Background

The genomic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a risk score of multiple variants. However, sex differences have not been fully examined in applications of genetic risk score (GRS) of CAD.

Methods

Using data from the UK Biobank, we constructed a CAD-GRS based on all known loci, 3 mediating trait-based (blood pressure, lipids, and body mass index) subscores, and a genome-wide polygenic risk score based on 1.1 million variants. The differences in genetic associations with prevalent and incident CAD between men and women were investigated among 317 509 unrelated individuals of the European ancestry. We also assessed interactions with sex for 161 individual loci included in the comprehensive GRS.

Results

F

SUBMITTER: Huang Y 

PROVIDER: S-EPMC7887043 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature