Ontology highlight
ABSTRACT:
SUBMITTER: Stamnaes J
PROVIDER: S-EPMC7887593 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Stamnaes Jorunn J Stray Daniel D Stensland Maria M Sarna Vikas K VK Nyman Tuula A TA Lundin Knut E A KEA Sollid Ludvig M LM
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210104 4
In celiac disease (CeD), gluten activates adaptive immune cells that cause damage to the small intestinal mucosa. Histological evaluation of intestinal biopsies allows for grading of disease severity. CeD can effectively be treated with a life-long gluten-free diet. Gluten challenge of treated CeD patients is used to confirm diagnosis and to test drug efficacy in clinical trials, but patients respond with different magnitudes to the same gluten challenge. In this study of 19 well-treated CeD pat ...[more]