Ontology highlight
ABSTRACT:
SUBMITTER: Kenkhuis B
PROVIDER: S-EPMC7887813 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kenkhuis Boyd B Somarakis Antonios A de Haan Lorraine L Dzyubachyk Oleh O IJsselsteijn Marieke E ME de Miranda Noel F C C NFCC Lelieveldt Boudewijn P F BPF Dijkstra Jouke J van Roon-Mom Willeke M C WMC Höllt Thomas T van der Weerd Louise L
Acta neuropathologica communications 20210217 1
Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown. Microglia have been identified as key players in the disease pathogenesis, and are highly reactive cells responding to aberrations such as increased iron levels. Therefore, using histological methods, multispectral immunofluorescence and an automated in-house developed microglia segmentation and analysis pipeline, we studied the occurrence ...[more]