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Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease.


ABSTRACT: During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months. (Funded by the Bill and Melinda Gates Foundation and others.).

SUBMITTER: Mbala-Kingebeni P 

PROVIDER: S-EPMC7888312 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease.

Mbala-Kingebeni Placide P   Pratt Catherine C   Mutafali-Ruffin Mbusa M   Pauthner Matthias G MG   Bile Faustin F   Nkuba-Ndaye Antoine A   Black Allison A   Kinganda-Lusamaki Eddy E   Faye Martin M   Aziza Amuri A   Diagne Moussa M MM   Mukadi Daniel D   White Bailey B   Hadfield James J   Gangavarapu Karthik K   Bisento Nella N   Kazadi Donatien D   Nsunda Bibiche B   Akonga Marceline M   Tshiani Olivier O   Misasi John J   Ploquin Aurelie A   Epaso Victor V   Sana-Paka Emilia E   N'kasar Yannick Tutu Tshia YTT   Mambu Fabrice F   Edidi Francois F   Matondo Meris M   Bula Bula Junior J   Diallo Boubacar B   Keita Mory M   Belizaire Marie R D MRD   Fall Ibrahima S IS   Yam Abdoulaye A   Mulangu Sabue S   Rimoin Anne W AW   Salfati Elias E   Torkamani Ali A   Suchard Marc A MA   Crozier Ian I   Hensley Lisa L   Rambaut Andrew A   Faye Ousmane O   Sall Amadou A   Sullivan Nancy J NJ   Bedford Trevor T   Andersen Kristian G KG   Wiley Michael R MR   Ahuka-Mundeke Steve S   Muyembe Tamfum Jean-Jacques JJ  

The New England journal of medicine 20210401 13


During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We i  ...[more]

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