Ontology highlight
ABSTRACT:
SUBMITTER: Huang K
PROVIDER: S-EPMC7888619 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Huang Kunling K Wu Yuchang Y Shin Junha J Zheng Ye Y Siahpirani Alireza Fotuhi AF Lin Yupei Y Ni Zheng Z Chen Jiawen J You Jing J Keles Sunduz S Wang Daifeng D Roy Sushmita S Lu Qiongshi Q
PLoS genetics 20210204 2
Recent advances in consortium-scale genome-wide association studies (GWAS) have highlighted the involvement of common genetic variants in autism spectrum disorder (ASD), but our understanding of their etiologic roles, especially the interplay with rare variants, is incomplete. In this work, we introduce an analytical framework to quantify the transmission disequilibrium of genetically regulated gene expression from parents to offspring. We applied this framework to conduct a transcriptome-wide a ...[more]