Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation.

ABSTRACT: Human pigmentation is a highly diverse and complex trait among populations and has drawn particular attention from both academic and non-academic investigators for thousands of years. Previous studies detected selection signals in several human pigmentation genes, but few studies have integrated contribution from multiple genes to the evolution of human pigmentation. Moreover, none has quantified selective pressures on human pigmentation over epochs and between populations. Here, we dissect dynamics and differences of selective pressures during different periods and between distinct populations with new approaches. We use genotype data of 19 genes associated with human pigmentation from 17 publicly available datasets and obtain data for 2346 individuals of six representative population gro

SUBMITTER: Huang X 

PROVIDER: S-EPMC7888712 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature