Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC7889546 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Liu Guoqing G Zhao Hongyu H Meng Hu H Xing Yongqiang Y Cai Lu L
Chromosoma 20210116 1
We present a deformation energy model for predicting nucleosome positioning, in which a position-dependent structural parameter set derived from crystal structures of nucleosomes was used to calculate the DNA deformation energy. The model is successful in predicting nucleosome occupancy genome-wide in budding yeast, nucleosome free energy, and rotational positioning of nucleosomes. Our model also indicates that the genomic regions underlying the MNase-sensitive nucleosomes in budding yeast have ...[more]