Ontology highlight
ABSTRACT:
SUBMITTER: Lechner M
PROVIDER: S-EPMC7889629 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Lechner Markus M Engleitner Thomas T Babushku Tea T Schmidt-Supprian Marc M Rad Roland R Strobl Lothar J LJ Zimber-Strobl Ursula U
Nature communications 20210217 1
Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a Notch2-dependent fate decision after splenic influx of immature transitional B cells. In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts. However, it is unclear whether FoB cells, which are in close contact with these DLL-1 expressing fibroblasts, can also differentiate to MZB cells if they receive a Notch2-signal. ...[more]