Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF-A induced angiogenesis.
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ABSTRACT:
SUBMITTER: Lu K
PROVIDER: S-EPMC7889723 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF-A induced angiogenesis.
Lu Kai K Bhat Madhavi M Peters Sara S Mitra Rita R Oberyszyn Tatiana T Basu Sujit S
Molecular carcinogenesis 20210122 3
Although beta 2 adrenergic receptors (β<sub>2</sub> ADR) are present in the keratinocytes, their role in cutaneous squamous cell tumorigenesis needs to be ascertained. For the first time, we report here that selective β<sub>2</sub> ADR antagonists by inhibiting β<sub>2</sub> ADR actions significantly retarded the progression of ultraviolet B (UVB) induced premalignant cutaneous squamous cell lesions. These antagonists acted by inhibiting vascular endothelial growth factor-A (VEGF) mediated angio ...[more]
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