Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC7889885 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Communications biology 20210217 1
NKCC and KCC transporters mediate coupled transport of Na<sup>+</sup>+K<sup>+</sup>+Cl<sup>-</sup> and K<sup>+</sup>+Cl<sup>-</sup> across the plasma membrane, thus regulating cell Cl<sup>-</sup> concentration and cell volume and playing critical roles in transepithelial salt and water transport and in neuronal excitability. The function of these transporters has been intensively studied, but a mechanistic understanding has awaited structural studies of the transporters. Here, we present the cry ...[more]