A Candidate Prognostic Biomarker Complement Factor I Promotes Malignant Progression in Glioma.

ABSTRACT: Objectives: Glioma is the most common and aggressive type of primary central nervous system (CNS) tumor in adults and is associated with substantial mortality rates. The aim of our study was to evaluate the prognostic significance and function of the complement factor I (CFI) in glioma. Materials and Methods: The expression levels of CFI in glioma tissues and the survival of the CFI^high and CFI^low patient groups were analyzed using The Cancer Genome Atlas (TCGA) database and Genotype-Tissue Expression (GTEx). The correlation between CFI expression and clinicopathological features of glioma was determined by univariate and multivariate Cox regression analyses in the Chinese Glioma Genome Atlas (CGGA) database. The functional role of CFI in glioma was esta

SUBMITTER: Cai X 

PROVIDER: S-EPMC7889977 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature