Ontology highlight
ABSTRACT:
SUBMITTER: Bai L
PROVIDER: S-EPMC7890106 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Bai Lei L Zhao Yongliang Y Dong Jiazhen J Liang Simeng S Guo Ming M Liu Xinjin X Wang Xin X Huang Zhixiang Z Sun Xiaoyi X Zhang Zhen Z Dong Lianghui L Liu Qianyun Q Zheng Yucheng Y Niu Danping D Xiang Min M Song Kun K Ye Jiajie J Zheng Wenchao W Tang Zhidong Z Tang Mingliang M Zhou Yu Y Shen Chao C Dai Ming M Zhou Li L Chen Yu Y Yan Huan H Lan Ke K Xu Ke K
Cell research 20210218 4
The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health. Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types. Remarkably, in vivo, increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV. Mo ...[more]