Dataset Information

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients?- Protocol for Proof-of-Concept Feasibility Trial.

ABSTRACT: Background: Atrial fibrosis and inflammation play important roles in perpetuating and initiating atrial fibrillation (AF). Although the fibrotic area can be visualized as a delayed enhancement area on late gadolinium enhancement magnetic resonance imaging (LGE-MRI), atrial inflammation has not yet been visualized on any imaging modality. We describe the protocol for a feasibility study to visualize atrial inflammation on positron emission tomography/MRI (PET/MRI). Methods?and?Results: This is a single-arm, prospective, open-label proof-of concept trial, involving AF patients after cryoballoon ablation (CBA). A total of 30 paroxysmal AF patients will be enrolled and undergo simultaneous PET/MRI for the assessment of regional ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake 1 day after the CBA. Furthermore, LGE-MRI will be performed before CBA, and at 1 and 4 weeks after assessing the regional LGE area. The main outcome measures will be (1) the feasibility of imaging inflammation in the left atrium on PET/MRI; and (2) the safety of the intervention. Conclusions: There are few data on the visualization of atrial inflammation using PET/MRI. Establishing the visualization methodology will contribute to elucidating the fundamental histopathologic findings of the progress to fibrosis, and to the planning and execution of a larger definitive trial to test the usefulness of PET/MRI.

SUBMITTER: Kiuchi K

PROVIDER: S-EPMC7890275 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients　- Protocol for Proof-of-Concept Feasibility Trial.

Kiuchi Kunihiko K Fukuzawa Koji K Nogami Munenobu M Watanabe Yoshiaki Y Takami Mitsuru M Mori Shumpei S Shimoyama Shinsuke S Negi Noriyuki N Kyotani Katsusuke K Hirata Ken-Ichi KI

Circulation reports 20200213 3

Background: Atrial fibrosis and inflammation play important roles in perpetuating and initiating atrial fibrillation (AF). Although the fibrotic area can be visualized as a delayed enhancement area on late gadolinium enhancement magnetic resonance imaging (LGE-MRI), atrial inflammation has not yet been visualized on any imaging modality. We describe the protocol for a feasibility study to visualize atrial inflammation on positron emission tomography/MRI (PET/MRI). Methods an ...[more]

PMID: 33693130

Similar Datasets

Project description:IntroductionAblation Index, also known as VISITAG SURPOINT™, is a novel lesion-quality marker that improves outcomes in radiofrequency (RF) catheter ablation of atrial fibrillation (AF). There is no direct evidence on the comparative effectiveness of RF ablation with Ablation Index and cryoballoon (CB). The objective of the present study was to conduct a matching-adjusted indirect comparison (MAIC) using individual patient-level data (IPD) to compare the effectiveness of RF ablation with Ablation Index to that of CB on recurrence of atrial arrhythmias 12 months after catheter ablation in patients with paroxysmal AF (PAF).MethodsIndividual patient-level data for RF ablation with Ablation Index were obtained from two studies: Solimene et al. [J Interv Card Electrophysiol 54(1):9-15, 2019] and Hussein et al. [J Cardiovasc Electrophysiol 28(9):1037-1047, 2017]. Comparable CB studies identified from a systematic literature review were pooled. Prognostic variables for adjustment were ranked a priori by several practicing electrophysiologists. In the absence of a common treatment arm between the Ablation Index and CB studies, an unanchored MAIC was conducted. Primary analysis compared the Solimene et al. study to pooled CB studies. A secondary analysis compared pooled RF ablation with Ablation Index studies to pooled CB studies. Several scenario and sensitivity analyses were conducted.ResultsPrimary analyses showed statistically significant reductions in the rate of arrhythmia recurrence with RF ablation with Ablation Index compared to CB in unmatched, unadjusted (HR 0.50, 95% CI 0.27-0.95) and matched (0.42, 0.21-0.86) analyses. Greater reductions in the rate of arrhythmia recurrence that favored RF ablation with Ablation Index were observed after matching and adjusting for age (0.41, 0.20-0.85), age and left ventricular ejection fraction (0.37, 0.16-0.88), and age, sex, and left ventricular ejection fraction (0.30, 0.13-0.71). Secondary and sensitivity analyses showed similar reductions.ConclusionsRadiofrequency ablation with Ablation Index was associated with reductions in recurrence of atrial arrhythmias at 12 months compared to CB in unmatched and unadjusted, matched, and matched and adjusted comparisons.

Dataset Information

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients?- Protocol for Proof-of-Concept Feasibility Trial.

Publications

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients　- Protocol for Proof-of-Concept Feasibility Trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients?- Protocol for Proof-of-Concept Feasibility Trial.

Publications

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients - Protocol for Proof-of-Concept Feasibility Trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Visualization of Inflammation After Cryoballoon Ablation in Atrial Fibrillation Patients　- Protocol for Proof-of-Concept Feasibility Trial.